Scientists in laboratory

Behind the science of the clinical study of Hyaluron-Filler

A clinical study that emphasizes the benefit of medical skincare in combination with dermatological treatment

Injection of Hyaluronic Acid is a popular standard treatment of aesthetic dermatologists to effectively treat facial wrinkles. But little research had been done into whether cosmetic anti-wrinkle products could successfully enhance the effect of these treatments – until now.

We always work in mixed teams; we combine our expertise in the formulation of skin care products with the input of aesthetic dermatologists to develop effective products that support their treatment.

Rainer Wolber, PhD, Head of Research & Development Eucerin

A pioneering clinical study conducted by Beiersdorf AG in cooperation with top aesthetic dermatologists has revealed that Eucerin Hyaluron-Filler successfully boosts the effect of Hyaluronic Acid fillers. What’s more, it’s the first skincare range in the world that’s been proven to do so.

Female scientist working in laboratory.
A constant effort has been put into the development of the Hyaluron-Filler formula.
Beiersdorf headquarter in Hamburg, Germany.
The idea for the clinical study was born in the Beiersdorf headquarter in Hamburg, Germany.

The study design

47 woman tested Eucerin Hyaluron-Filler Day Cream and Night Cream, plus Eye Cream twice a day.

Forty-seven women received Hyaluronic Acid filler injections in their nasiolabial folds (laugh lines) and/or around their eyes (crow’s feet). They also applied Eucerin Hyaluron-Filler products to one side of their face and vehicle creams to the other twice a day – a routine that started 4 weeks before the injections, and continued for 14 weeks after.

Illustration of study period

The vehicle creams did not contain the active ingredients of Eucerin Hyaluron-Filler, Hyaluronic Acid and Glycine Saponin, in every way, with one critical difference: they lacked the active ingredients, Hyaluronic Acid and Glycine Saponin, that make Eucerin Hyaluron-Filler so effective at reducing fine lines and deep wrinkles.

Illustration of study testing

Crucially, the study was “double-blind” – meaning neither the women nor the investigating dermatologists knew which side of the face Eucerin Hyaluron-Filler or the vehicles had been applied to.

According to Rainer Wolber, the study sets a high benchmark for cosmetic products as “we choose a double- blind vehicle-controlled design that is usually used in the pharmaceutical industry for drug testing.”

The results

The study’s results were conclusive. Applying Eucerin Hyaluron-Filler twice daily was proven to visibly boost the effects of wrinkle filler treatments.

“The results surpassed our expectations and demonstrated that the regular daily application of Eucerin Hyaluron-Filler, with its unique ingredient combination, can help to enhance the effect of Hyaluronic Acid injections. The products were very well tolerated and increased skin moisture, “ Wolber said. “And the participants’ self-assessments paint a clear picture of the extent to which the positive effect is perceived by users.”

It was a completely new concept for the study design

Dr. Prager / Supervising Dermatologist, Dermatologikum Hamburg

Clinical study shown on elderly women´s faces.