Behind the science – Of Eucerin Hyaluron-Filler

Skin’s structure changes as we age: fine lines and wrinkles appear first and deepen over time. As we continue to mature, skin’s volume and firmness, radiance and, later on, its elasticity all gradually reduce.

Eucerin Hyaluron-Filler has been specially formulated to address the first signs of aging such as fine lines and wrinkles. Eucerin’s unique blend of high and low molecular Hyaluronic Acid, Glycine Saponin, and Enoxolone delivers a targeted approach to visibly plumping deep wrinkles for younger looking skin.

“Most of us start to develop fine lines and wrinkles in our early 30s,” explains Dr Sven Fey, R&D Category Head at Eucerin. Skin aging, like aging in general, is inevitable and there are several different factors that govern it. There’s little we can do about the internal, biological factors such as our genetics and our hormones, but we can take lifestyle steps to avoid and reduce some of the external factors that speed up the aging process: and the most significant to those is over-exposure to the sun.

“Some 90% of premature aging is caused by the sun,” says Dr Fey. “When we set out to create the Eucerin Hyaluron-Filler range, we wanted to protect skin from sun damage as well as to create a formula that would give skin the hydration it needs and plump up deep wrinkles.”

With more than 100 years of clinical experience and expertise, and products that are proven to deliver results, Eucerin is a trusted brand amongst dermatologists worldwide. “94% of the dermatologists we spoke to said that they found Hyaluron injections the most versatile way to deal with skin-aging concerns,” explains Dr Fey. “We wanted to create a topical, skincare formula that would offer the wrinkle-filling benefits of Hyaluronic Acid without the need for invasive treatment or, alternatively, support the results of dermatologist-led treatments.”

Research began on how to maximize the benefits of Hyaluronic Acid in a topical formula. “Hyaluronic Acid is a powerful moisturizer,” says Dr Fey. Produced naturally in young skin our cells produce less Hyaluronic Acid as we age: skin becomes drier (sometimes referred to as age-induced dryness) and fine lines and wrinkles become more visible on skin’s surface. “We combined two types of Hyaluronic Acid – high and low molecular - in the Eucerin Hyaluron-Filler formula for maximum benefits.” explains Dr Fey.

• High molecular Hyaluronic Acid remains on skin’s surface and works to improve hydration in the outermost layer of the epidermis – where fine lines and winkles originate. 
• With molecules that are 40 times smaller² than those of high molecular Hyaluronic Acid, Low molecular Hyaluronic Acid penetrates further into the epidermal layers where it stimulates skin’s own production of Hyaluronic Acid.

High molecular Hyaluronic Acid

Low molecular Hyaluronic Acid

“Using both molecular weights means that the formula addresses surface fine lines and deeper wrinkles, “says Dr. Fey, “but we didn’t just stop there”. Dr Fey and his team went on to enhance the effectiveness of the Hyaluronic Acid by adding Glycine Saponin to the formula. An extract of the soya bean it is, as he explains, “one of the most effective stimulators of Hyaluronic Acid in the dermal layers of skin”. It’s been independently proven to increase Hyaluronic Acid production in skin cells by up to 256%³.

^{Beiersdorf In vitro research: Saponins – A New Generation of Hyaluronan-Stimulating Actives for Human Skin S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany}

In 2021, Enoxolone was also added to the formula to slow down the degradation rate of Hyaluronic Acid in skin. The degradation happens via the enzyme Hyaluronidase (HYAL1) which breaks down skin’s own Hyaluronic Acid. If this is not inhibited, the levels of Hyaluronic Acid in skin will decrease. Enoxolone slows down the degradation rate of Hyaluronic Acid in skin by more than 50%. 

^{Beiersdorf In vitro research: Saponins – A New Generation of Hyaluronan-Stimulating Actives for Human Skin S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany}

The team then worked with their base formula to add superior UVB and UVA filters to create three day creams offering a range of sun protection to suit all skin types: Hyaluron-Filler Day SPF 15 for dry skin, Hyaluron-Filler Day SPF 15 for normal to combination skin, and Hyaluron-Filler Day SPF 30 (for all skin types).

To enhance the benefits of the day, night, and eye creams, the range also offers a Concentrate and a dual-efficacy night peel and serum. The Eucerin Hyaluron-Filler Night Peeling & Serum has been formulated to exfoliate and refine skin texture. “It’s a double chamber product and unique in anti-aging skincare “explains Dr Fey. “The gel formula in the first chamber contains both high and low molecular Hyaluronic Acid4, while the emulsion in the other chamber contains Glycine Saponin and an effective AHA (alpha-hydroxy-acid) Complex for exfoliation. AHAs are commonly known as Fruit Acids.” When combined together the gel and emulsion promote skin cell renewal and refine skin while plumping up even the deepest wrinkles. “We recommend that, for best results, you use it prior Eucerin Hyaluron-Filler Night” adds Dr Fey.

The range is clinically and dermatologically proven to plump up even the deepest wrinkles for a rejuvenated look.

Impressive results for Eucerin Hyaluron-Filler 

The range is clinically and dermatologically proven to plump up deep wrinkles for smother, radiant, and younger looking skin.

Research includes Product-in-use (PIU) studies on the SPF 15 day creams5,6, the eye cream5 and the night cream5. All studies were conducted amongst regular users of anti-aging products who reported the following impressive results after four weeks of use: 

Eucerin Hyaluron-Filler Day SPF 15 for dry skin: 

2 weeks: 88% / 4 weeks: 99%: fine lines and wrinkles are visibly reduced
2 weeks: 99% / 4 weeks: 100%: rejuvenates the look of my skin
2 weeks: 96% / 4 weeks: 100%: makes my skin visibly & noticeably smoother
2 weeks: 93% / 4 weeks: 100%: Prevents the formation of new lines and wrinkles
2 weeks: 88% / 4 weeks: 98%: prevents the deepening of wrinkles
2 weeks: 98% / 4 weeks: 100% moisturizes intensively

Eucerin Hyaluron-Filler Day SPF 15 for normal to combination skin:

88%: visibly reduces fine lines - 88%: prevents the formation of fine lines and wrinkles 
87%: leaves a long-lasting, non-oily skin feel - 87%: leaves skin visibly and noticeably smoother 
82%: an ideal make-up base 

Eucerin Hyaluron-Filler Eye SPF 15: 

2 weeks: 91% / 4 weeks: 100%: provides my skin around the eyes with a rejuvenated look
2 weeks: 83% / 4 weeks: 98%: fine lines and wrinkles are visibly reduced
2 weeks: 86% / 4 weeks: 99%: makes my skin visibly & noticeably smoother
2 weeks: 95% / 4 weeks: 100%: prevents the formation of new lines and wrinkles
2 weeks: 88% / 4 weeks: 97%: prevents the deepening of wrinkles

Eucerin Hyaluron-Filler Night: 

2 weeks: 86% / 4 weeks: 100%: fine lines & wrinkles are visibly reduced
2 weeks: 93% / 4 weeks: 100%: prevents the formation of new lines and wrinkles
2 weeks: 88% / 4 weeks: 98%: supports the skin’s regeneration overnight
2 weeks: 99% / 4 weeks: 99%: has a very intense caring effect

Eucerin Hyaluron-Filler Day SPF 30:

2 weeks: 93% / 4 weeks: 98%: rejuvenates the look of my skin
2 weeks: 87% / 4 weeks: 97%: makes my skin visibly & noticeably smoother
2 weeks: 87% / 4 weeks: 98%: Prevents the formation of new lines and wrinkles
2 weeks: 90% / 4 weeks: 98% moisturizes intensively

Eucerin Hyaluron-Filler Concentrate:

2 weeks: 96% / 4 weeks: 99%: instantly delivers a perceivable effect
2 weeks: 95% / 4 weeks: 98%: makes my skin visibly & noticeably smoother
2 weeks: 93% / 4 weeks: 98%: prevents the formation of new lines and wrinkles
2 weeks: 82% / 4 weeks: 98%: makes me feel younger

“These results, as well as results from other clinical and dermatological studies, prove the efficacy of our products,” concludes Dr. Fey. “Eucerin Hyaluron-Filler helps women to address the first signs of aging without invasive treatment and can also be used in conjunction with dermatological treatments to support and extend results.”